5-CHLORO-1,3-BENZODIOXOL-4-AMINE Basic Product Information

Product Name	5-CHLORO-1,3-BENZODIOXOL-4-AMINE	CAS	379228-45-2
Synonyms	(5-Chloro-1,3-benzodioxol-4-yl)amine;(5-Chlorobenzodioxol-4-yl)amine; 5-Chloro-1,3-benzodioxol-4-amine;6-Chloro-2,3-methylenedioxyaniline	Molecular Formula	C7H6 Cl N O2
EINECS Number		Molecular Structure
Appearance	Light Yellow Powder
Purity
Supply Ability

5-CHLORO-1,3-BENZODIOXOL-4-AMINE Quality documents

5-CHLORO-1,3-BENZODIOXOL-4-AMINE Appearance/Package/Shipping/Storage

package

storage condition

Store in cool & dry place,Keep away from strong light and heat

5-CHLORO-1,3-BENZODIOXOL-4-AMINE Application

5-CHLORO-1,3-BENZODIOXOL-4-AMINE literature

Discovery of a New Class of Anilinoquinazoline Inhibitors with High Affinity and Specificity for the Tyrosine Kinase Domain of c-Src

Plé, Patrick A.,Green, Tim P.,Hennequin, Laurent F.,Curwen, Jon,Fennell, Michael,Allen, Jack,Lambert-Van Der Brempt, Christine,Costello, Gerard

, p. 871 - 887 (2007/10/03)

Deregulated activity of the nonreceptor tyrosine kinase c-Src is believed to result in signal transduction, cytoskeletal and adhesion changes, ultimately promoting a tumor-invasive phenotype. We report here the discovery of a new class of anilinoquinazoline inhibitors with high affinity and specificity for the tyrosine kinase domain of the c-Src enzyme. Special attention was directed toward finding inhibitors selective against KDR tyrosine kinase in order to ensure that the in vivo profile of a specific Src inhibitor could be determined. The 4-aminobenzodioxole quinazoline series gave compounds with excellent potency and selectivity. The most interesting compounds were evaluated in vivo and displayed good pharmacokinetics following oral dosing. Compounds such as the aminobenzodioxoles were shown to be potent inhibitors of tumor growth in a c-Src-transformed 3T3 xenograft model in vivo, resulting in more than 90% growth inhibition at doses as low as 6 mg/kg po once daily. Src tyrosine kinase inhibitors such as these may provide a novel therapeutic modality for targeting cancer invasion and metastasis.

QUINAZOLINE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER

-

Page/Page column 71, (2008/06/13)

The invention concerns quinazoline derivatives of Formula (I) wherein each of Z, m, R¹, n, R³,Z² and R¹⁴ have any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an anti-invasive or anti-proliferative agent in the containment and/or treatment of solid tumour disease.

SUBSTITUTED 3-CYANOQUINOLINES AS MEK INHIBITORS

-

Page 71; 94, (2010/11/30)

The invention concerns quinoline derivatives of Formula (I) wherein each of Z¹, m, R¹, n, R³, Z² and R¹⁴ have any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an anti-invasive or anti-proliferative agent in the containment and/or treatment of solid tumour disease.

5-CHLORO-1,3-BENZODIOXOL-4-AMINE Upstream and downstream

379228-45-2 Upstream product

• 379229-84-2

  tert-butyl (5-chloro-1,3-benzodioxol-4-yl)carbamate 

• 7228-38-8

  5-chloro-1,3-benzodioxole 

• 379229-83-1

  5-chloro-1,3-benzodioxole-4-carboxylic acid 

379228-45-2 Downstream Products

• 536740-72-4

  7-(benzyloxy)-N-(5-chloro-1,3-benzodioxol-4-yl)-5-[(1-methylpiperidin-4-yl)oxy]quinazolin-4-amine 

• 536740-63-3

  tert-butyl 4({7-(benzyloxy)-4-[(5-chloro-1,3-benzodioxol-4-yl)amino]quinazolin-5-yl}oxy)piperidine-1-carboxylate 

• 379230-38-3

  7-fluoro-N-(5-chloro-1,3-benzodioxol-4-yl)-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine 

• 945393-39-5

  N~4~-(5-Chloro-1,3-benzodioxol-4-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine 

• 945394-90-1

  3-({4-[(5-Chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl}amino)benzoic acid 

• 945396-75-8

  3-({4-[(5-Chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl}amino)benzoyl chloride 

• 945394-92-3

  3-({4-[(5-Chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl}amino)-N,N-dimethylbenzamide 

• 945395-53-9

  N'-(5-chlorobenzo[1,3]dioxol-4-yl)-N'-methyl-N-phenyl-pyrimidine-2,4-diamine 

Related Products

• 

  2-Methyl anthraquinone

  CAS NO.：

  84-54-8

  Molecular Formula ：

  C15H10O2

• 

  2-methyl tetradecane

  CAS NO.：

  1560-95-8

  Molecular Formula ：

  C15H32

• 

  Ammonium cupric chloride dihydrate

  CAS NO.：

  10060-13-6

  Molecular Formula ：

  Cl4CuH6NO-

• 

  N,N''-(methylenedi-4,1-phenylene)bis N'-cyclohexyl-Urea

  CAS NO.：

  58890-25-8

  Molecular Formula ：

  C27H36N4O2

• 

  Methyl 2-oxotetrahydrofuran-3-carboxylate

  CAS NO.：

  19406-00-9

  Molecular Formula ：

  C6H8O4