2-AMINO-4'-METHOXYACETOPHENONE HYDROCHLORIDE Basic Product Information

Product Name	2-AMINO-4'-METHOXYACETOPHENONE HYDROCHLORIDE	CAS	3883-94-1
Synonyms	Acetophenone,2-amino-4'-methoxy-, hydrochloride (7CI,8CI);Ethanone,2-amino-1-(4-methoxyphenyl)-, hydrochloride (9CI);2-Amino-1-(4-methoxyphenyl)ethanone hydrochloride;a-Amino-p-methoxyacetophenone hydrochloride;	Molecular Formula	C9H12ClNO2
EINECS Number		Molecular Structure
Appearance	Light Yellow Powder
Purity	97.00%
Supply Ability

2-AMINO-4'-METHOXYACETOPHENONE HYDROCHLORIDE Quality documents

2-AMINO-4'-METHOXYACETOPHENONE HYDROCHLORIDE Appearance/Package/Shipping/Storage

package

storage condition

Store in cool & dry place,Keep away from strong light and heat

2-AMINO-4'-METHOXYACETOPHENONE HYDROCHLORIDE Application

2-AMINO-4'-METHOXYACETOPHENONE HYDROCHLORIDE literature

The reaction of prop-2-ynylsulfonium salts and sulfonyl-protected β-amino ketones to epoxide-fused 2-methylenepyrrolidines and S-containing pyrroles

Jia, Tingting,Zeng, Gongruixue,Zhang, Chong,Zeng, Linghui,Zheng, Wenya,Li, Siyao,Wu, Keyi,Shao, Jiaan,Zhang, Jiankang,Zhu, Huajian

supporting information, p. 2657 - 2660 (2021/03/16)

A novel divergent domino annulation reaction of prop-2-ynylsulfonium salts with sulfonyl-protected β-amino ketones has been developed, affording various epoxide-fused 2-methylenepyrrolidines and S-containing pyrroles in moderate to excellent yields. Prop-2-ynylsulfonium salts act as C₂synthons in the reactions providing a promising epoxide-fused skeleton in a single operation with readily accessible starting materials.

Design, synthesis and evaluation of novel 5-phenylthiophene derivatives as potent fungicidal of Candida albicans and antifungal reagents of fluconazole-resistant fungi

Cheng, Maosheng,Cui, Hengxian,Jiang, Hong,Li, Song,Liu, Lei,Su, Xin,Sun, Yin,Wu, Tianxiao,Yin, Wenbo,Zhang, Yuxin,Zhao, Dongmei,Zhao, Liyu,Zheng, Yang

, (2021/08/13)

A series of 5-phenylthiophene derivatives with novel structures were designed and synthesized to combat the increasing incidence of susceptible and drug-resistant fungal infections. The antifungal activity of the synthesized compounds was assessed against seven susceptible strains and six fluconazole-resistant strains. It is especially encouraging that compounds 17b and 17f displayed significant antifungal activities against all tested strains. Furthermore, the potent compounds 17b and 17f could prevent the formation of fungi biofilms and 17f displayed satisfactory fungicidal activity. Preliminary mechanistic studies showed that the potent antifungal activity of compound 17f stemmed from inhibition of C. albicans CYP51. In addition, Compounds 17b and 17f were almost nontoxic to mammalian A549, MCF-7, and THLE-2 cells. These results strongly suggested that compounds 17b and 17f are promising as novel antifungal drugs.

Synthesis of a New Phorbazole and Its Derivatives

Louglin, Wendy A.,Muderawan, I Wayan,Young, David J.

, (2021/11/30)

Phorbazoles are chlorinated marine alkaloids containing pyrrole, oxazole and phenol ring units, and differ in the number and positions of chlorine atoms. They are isolated from sea sponges and nudibranchs. In this work, a convenient synthetic method leading to a new phorbazole and its derivatives is developed. This synthesis of synthetic phorbazole G and its derivatives is achieved in seven steps in good overall yields of 26-52%. It involves formation of the pyrrole-oxazole skeleton followed by chlorination. The pyrrole-oxazole skeleton is synthesized from pyrrole and substituted acetophenones, and the key step involves cyclodehydration of amide intermediates to give protected oxazoles, followed by hydrolysis.

Synthesis, characterization, COX1/2 inhibition and molecular modeling studies on novel 2-thio-diarylimidazoles

?ahin, Zafer,Bender, Ceysu,Berk, Bark?n,Biltekin Kaleli, Sevde Nur,Demirayak, ?eref,Ko?o?lu Kalkan, Melike,Yurtta?, Leyla

, p. 1841 - 1853 (2022/01/08)

Heterocyclic compounds with diaryl substituents have been a milestone approach for selective cyclooxygenase 2 (COX 2) inhibition by bioisosteric replacements and modifications. It is also known that thiazole derivatives have different pharmacological acti

2-AMINO-4'-METHOXYACETOPHENONE HYDROCHLORIDE Upstream and downstream

3883-94-1 Upstream product

• 100-97-0

  hexamethylenetetramine 

• 2196-99-8

  2-chloro-1-(4-methoxyphenyl)ethanone 

• 46318-58-5

  4-methoxybenzoylnitromethane 

• 129972-93-6

  C₁₁H₁₁NO₄ 

• 7770-25-4

  (4-methoxy-phenacyl)-hexamethylenetetraminium; bromide 

• 93102-87-5

  5-(4-Chloro-benzyl)-oxazole-4-carboxylic acid methyl ester 

• 151427-04-2

  2-(p-methoxyphenyl)ethan-1,2-dion-1-oxime sodium salt 

• 18197-26-7

  sodium diformamide 

3883-94-1 Downstream Products

• 69163-82-2

  5-(4-methoxyphenyl)-2-methyl-1,3-oxazole 

• 72997-56-9

  2-(4-ethyl-phenyl)-5-(4-methoxy-phenyl)-thiazole 

• 72997-57-0

  5-(4-methoxy-phenyl)-2-(4-propyl-phenyl)-thiazole 

• 72997-58-1

  2-(4-butyl-phenyl)-5-(4-methoxy-phenyl)-thiazole 

• 72997-59-2

  5-(4-methoxy-phenyl)-2-(4-pentyl-phenyl)-thiazole 

• 72997-60-5

  2-(4-hexylphenyl)-5-(4-methoxyphenyl)-1,3-thiazole 

• 72997-50-3

  2-(4-hexyloxy-phenyl)-5-(4-methoxy-phenyl)-thiazole 

• 72997-52-5

  5-(4-methoxy-phenyl)-2-(4-octyloxy-phenyl)-thiazole 

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