2-Aminoadenosine Basic Product Information

Product Name	2-Aminoadenosine	CAS	2096-10-8
Synonyms	2-(2,6-diaminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol;2-Amino-adenosine;9H-Purine-2,6-diamine, 9-.beta.-D-ribofuranosyl-;2,6-Diaminopurinosine;Adenosine, 2-amino-;9-beta-Ribosyl-2,6-diaminopurine;(2R,3R,4R,5R)-2-(2,6-diaminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol;9H-Purine, 2,6-diamino-9-beta-D-ribofuranosyl- (8CI);2,6-Diaminonebularine;9H-Purine-2,6-diamine, 9-beta-D-ribofuranosyl-;2-Aminoadenosine, 2,6-Diaminopurine riboside;	Molecular Formula	C10H14N6O4
EINECS Number	209-610-8	Molecular Structure
Appearance	Light Yellow Powder
Purity	98.00%
Supply Ability

2-Aminoadenosine Quality documents

2-Aminoadenosine Appearance/Package/Shipping/Storage

package

storage condition

Store in cool & dry place,Keep away from strong light and heat

2-Aminoadenosine Application

2-Aminoadenosine literature

High-throughput five minute microwave accelerated glycosylation approach to the synthesis of nucleoside libraries

Bookser, Brett C.,Raffaele, Nicholas B.

, p. 173 - 179 (2007/10/03)

The Vorbrueggen glycosylation reaction was adapted into a one-step 5 min/130 °C microwave assisted reaction. Triethanolamine in acetontrile containing 2% water was determined to be optimal for the neutralization of trimethylsilyl inflate allowing for direct MPLC purification of the reaction mixture. When coupled with a NH₃/methanol deprotection reaction, a high-throughput method of nucleoside library synthesis was enabled. The method was demonstrated by examining the ribosylation of 48 nitrogen containing heteroaromatic bases that included 25 purines, four pyrazolopyrimidines, two 8-azapurines, one 2-azapurine, two imidazopyridines, two benzimidazoles, three imidazoles, three 1,2,4-triazoles, two pyrimidines, two 3-deazapyrimidines, one quinazolinedione, and one alloxazine. Of these, 32 yielded single regioisomer products, and six resulted in separable mixtures. Seven examples provided inseparable regioisomer mixtures of -two to three compounds (16 nucleosides), and three examples failed to yield isolable products. For the 45 single isomers isolated, the average two-step overall yield ± SD was 26 ± 16%, and the average purity ± SD was 95 ± 6%. A total of 58 different nucleosides were prepared of which 15 had not previously been accessed directly from glycosylation/deprotection of a readily available base.

Synthesis of 2-phenylaminoadenosine from imidazole nucleosides

Omura,Marumoto,Furukawa

, p. 1870 - 1875 (2007/10/02)

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2-Aminoadenosine Upstream and downstream

2096-10-8 Upstream product

• 622-34-4

  1-phenylcyanamide 

• 23192-64-5

  5-amino-1-β-D-ribofuranosyl-1H-imidazole-4-carbonitrile 

• 67-56-1

  methanol 

• 3387-63-1

  2-amino-6-chloro-9-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)purine 

2096-10-8 Downstream Products

• 146-78-1

  2-fluoroadenosine 

• 1818-71-9

  isoguanosine 

• 80791-88-4

  2,6-diamino-9-(3-O-methyl-β-D-ribofuranosyl)purine 

• 80791-87-3

  2-amino-2'-O-methyladenosine 

• 121231-93-4

  2,6-diamino-9-(<2'-O-(p-tosyl)sulfonyl>-β-D-ribofuranosyl)purine 

• 81102-44-5

  9-(β-D-ribofuranosyl)-2,6-diamino-8-bromopurine 

• 159639-71-1

  N²,N⁶-dibenzoyl-2-aminoadenosine 

• 30685-38-2

  2',3'-O-isopropylidene-2-aminoadenosine 

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