Products
2,4'-Dichloroacetophenone
Another name：Ethanone; 2-chloro-1-(4-chlorophenyl)-; 2-chloro-1-(4-chlorophenyl)ethanone;
CasNo: 937-20-2 Purity： >99% Molecular Structure： C8H6Cl2O
2,4'-Dichloroacetophenone Basic Product Information
| Product Name | 2,4'-Dichloroacetophenone | CAS | 937-20-2 |
| Synonyms | Ethanone; 2-chloro-1-(4-chlorophenyl)-; 2-chloro-1-(4-chlorophenyl)ethanone; |
Molecular Formula | C8H6Cl2O |
| EINECS Number | 189.04 | Molecular Structure | |
| Appearance | White Powder |
 |
|
| Purity | >99% | ||
| Supply Ability | 30-50T Per Month | ||
2,4'-Dichloroacetophenone Quality documents
2,4'-Dichloroacetophenone Appearance/Package/Shipping/Storage
Package
25kg/Cardboard Drum
Storage condition
Recommended storage temperature 5-20 °C, and Store in dry place, keep away from strong light & heat.
2,4'-Dichloroacetophenone Application
Intermediates, pharmaceutical industry, agricultural chemicals, materials science.
2,4'-Dichloroacetophenone literature
Tris-(2-pyridylmethyl)amine-ligated Cu(II) 1,3-diketonate complexes: Anaerobic retro-Claisen and dehalogenation reactivity of 2-chloro-1,3-diketonate derivatives
Elsberg, Josiah G. D.,Anderson, Stephen N.,Tierney, David L.,Reinheimer, Eric W.,Berreau, Lisa M.
, p. 1712 - 1720 (2021/02/22)
We report synthetic, structural and reactivity investigations of tris-(2-pyridylmethyl)amine (TPA)-ligated Cu(ii) 1,3-diketonate complexes. These complexes exhibit anaerobic retro-Claisen type C-C bond cleavage reactivity which exceeds that found in analo
A practical synthesis of α-bromo/iodo/chloroketones from olefins under visible-light irradiation conditions
Wang, Zhihui,Wang, Lei,Wang, Zhiming,Li, Pinhua,Zhang, Yicheng
supporting information, p. 429 - 432 (2020/02/29)
A practical synthesis of α-bromo/iodo/chloroketones from olefins under visible-light irradiation conditions has been developed. In the presence of PhI(OAc)2 as promoter and under ambient conditions, the reactions of styrenes and triiodomethane undergo the transformation smoothly to deliver the corresponding α-iodoketones without additional photocatalyst in good yields under sunlight irradiation. Meanwhile, the reactions of styrenes with tribromomethane and trichloromethane generate the desired α-bromoketones and α-chloroketones in high yields by using Ru(bpy)3Cl2 as a photocatalyst under blue LED (450–455 nm) irradiation.
Facile Synthesis of α-Haloketones by Aerobic Oxidation of Olefins Using KX as Nonhazardous Halogen Source
Luo, Zhibin,Meng, Yunge,Gong, Xinchi,Wu, Jie,Zhang, Yulan,Ye, Long-Wu,Zhu, Chunyin
supporting information, p. 173 - 177 (2020/01/02)
An operationally simple and safe synthesis of α-haloketones using KBr and KCl as nonhazardous halogen sources is reported. It involves an iron-catalysed reaction of alkenes with KBr/KCl using O2 as terminal oxidant under the irradiation of visible-light. This strategy avoids the risks associated with handling halo-contained electrophiles (Cl2, Br2, NCS, NBS). The process is tolerant to several functional groups, and extended to a range of substituted styrenes in up to 89% yield. A radical reaction pathway is proposed based on control experiments and spectroscopy studies.
A new exploration towards aminothiazolquinolone oximes as potentially multi-targeting antibacterial agents: Design, synthesis and evaluation acting on microbes, DNA, HSA and topoisomerase IV
Wang, Liang-Liang,Battini, Narsaiah,Bheemanaboina, Rammohan R. Yadav,Ansari, Mohammad Fawad,Chen, Jin-Ping,Xie, Yun-Peng,Cai, Gui-Xin,Zhang, Shao-Lin,Zhou, Cheng-He
, p. 166 - 181 (2019/07/02)
This work did a new exploration towards aminothiazolquinolone oximes as potentially multi-targeting antimicrobial agents. A class of novel hybrids of quinolone, aminothiazole, piperazine and oxime fragments were designed for the first time, conveniently synthesized as well as characterized by 1H NMR, 13C NMR and HRMS spectra. Biological activity showed that some of the synthesized compounds exhibited good antimicrobial activities in comparison with the reference drugs. Especially, O-methyl oxime derivative 10b displayed excellent inhibitory efficacy against MRSA and S. aureus 25923 with MIC values of 0.009 and 0.017 mM, respectively. Further studies indicated that the highly active compound 10b showed low toxicity toward BEAS-2B and A549 cell lines and no obvious propensity to trigger the development of bacterial resistance. Quantum chemical studies have also been conducted and rationally explained the structural features essential for activity. The preliminarily mechanism exploration revealed that compound 10b could not only exert efficient membrane permeability by interfering with the integrity of cells, bind with topoisomerase IV–DNA complex through hydrogen bonds and π-π stacking, but also form a steady biosupramolecular complex by intercalating into DNA to exert the efficient antibacterial activity. The supramolecular interaction between compound 10b and human serum albumin (HSA) was a static quenching, and the binding process was spontaneous, where hydrogen bonds and van der Waals force played vital roles in the supramolecular transportation of the active compound 10b by HSA.
2,4'-Dichloroacetophenone Upstream and downstream
937-20-2 Upstream product
99-91-2
para-chloroacetophenone
122-01-0
4-chloro-benzoyl chloride
79-04-9
chloroacetyl chloride
108-90-7
chlorobenzene
5333-82-4
2,2,2-trichloro-1-(4-chloro-phenyl)-ethanol
1073-67-2
4-vinylbenzyl chloride
3391-10-4
1-(p-chlorophenyl)ethyl alcohol
873-73-4
4-n-chlorophenylacetylene
937-20-2 Downstream Products
74103-96-1
1-(4-chlorophenyl)-2-(piperidin-1-yl)ethanone
19909-04-7
1-(4-chloro-phenyl)-2-(4-methyl-piperazin-1-yl)-ethanone
486439-05-8
4-[2-(4-chloro-phenyl)-2-oxo-ethyl]-piperazine-1-carboxylic acid ethyl ester
32157-73-6
1-(p-chlorophenyl)-2,3-epoxy-3-phenylpropan-1-one
103441-91-4
2-ethylamino-1-(4-chloro-phenyl)-ethanone; hydrochloride
24840-75-3
4-(4-chlorophenyl)-2-methyl-1,3-thiazole
80268-72-0
2-chloro-1,1-bis-(4-chloro-phenyl)-ethanol
6305-05-1
2-(4-chlorophenyl)-N-hydroxy-2-oxoethanimidoyl chloride
Related Products
Please leave us a message or contact us using the following methods. We will reply to you as soon as possible and provide you with the most sincere service, thank you.
Hangzhou Office： Hangzhou Office:Suite#210A,No.1 Building, No.182 Zhaohui Road, Xiacheng District, Hangzhou City, Zhejiang Province,China.
Tel： +(86) 0571 8716 2326
Fax： +(86) 571 8719 1975
Phone： +(86) 177 6713 0763
Email： sales@kaimosi.com
WhatsApp： +(86)177 6713 0763
