1197-18-8｜Tranexamic Acid｜Kaimosi BioChem Tech Co., Ltd

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Tranexamic Acid Basic Product Information

Product Name	Tranexamic Acid	CAS	1197-18-8
Synonyms	Amstat;trans-cyclohexanecarboxylic acid;4-(aminomethyl)cyclohexanecarboxylic acid	Molecular Formula	C8H15NO2
EINECS Number	214-818-2	Molecular Structure
Appearance	White powder
Purity	99%-101%
Supply Ability	800KG Per Month

Tranexamic Acid Quality documents

KMS-COA-Tranexamic Acid (3).pdf

KMS- MSDS-Tranexamic acid (2).pdf

Tranexamic Acid Appearance/Package/Shipping/Storage

Package

25KG/Drum,Or according to customer needs

Storage condition

Cool and dry place

Tranexamic Acid Application

Tranexamic acid is a hemostatic agent that can treat or prevent abnormal bleeding caused by hyperfibrinolysis by inhibiting fibrinolysis. It can also be used to reduce melanin production and for anti-aging and anti-photoaging purposes.

Tranexamic Acid literature

Method for synthesizing formic acid

, (2022/04/03)

The invention discloses a synthesis process of tranexamic acid (I), which comprises the following steps of: performing esterification reaction on 3-cyclohexene formic acid (V) serving as a raw material to obtain an intermediate 3-cyclohexene formate (IV); carrying out carbonyl insertion reaction on the intermediate (IV) and carbon monoxide/hydrogen mixed gas or synthesis gas in the presence of a catalyst to obtain an intermediate 4-formyl cyclohexane-1-formate (III) with high selectivity; carrying out reductive amination on the intermediate (III) to obtain an intermediate 4-aminomethyl cyclohexane formate (II); and finally hydrolyzing and transforming the intermediate (II) to obtain tranexamic acid (I). The raw materials are cheap and easy to obtain, the carbon monoxide carbonyl insertion reaction is green and environment-friendly, the route is simple and efficient, and a new method is provided for synthesis of tranexamic acid (I).

READY-TO-USE TRANEXAMIC ACID INTRAVENOUS SOLUTION

, (2020/04/09)

Ready-to-use, stable aqueous intravenous tranexamic acid compositions are provided.

A 4-acetamidomethyl methyl cyclohexyl method for producing methyl formate

Paragraph 0051-0053, (2017/02/28)

The invention relates to a preparation method of methyl 4-acetylaminomethyl hexahydrobenzoate. The method comprises the following steps: adding methyl paracyanobenzoate into a reaction kettle, adding a metal catalyst I and a cocatalyst II, heating while stirring to react under hydrogen gas conditions for 6-10 hours by using acetic anhydride as a solvent, filtering, and distilling to obtain the methyl acetylaminomethyl benzoate; and adding the obtained methyl acetylaminomethyl benzoate into a reaction kettle, adding a solvent V, a metal catalyst III and a cocatalyst IV, heating while stirring to completely react under hydrogen gas conditions, filtering, and distilling to recover the solvent, thereby obtaining the methyl 4-acetylaminomethyl hexahydrobenzoate. The synthesis technique of preparing the methyl 4-acetylaminomethyl hexahydrobenzoate from the initial raw material methyl paracyanobenzoate has the advantages of accessible raw materials, low cost, high yield and the like, and is simple to operate and suitable for industrial production. The product can be further used for preparing the trans-4-aminomethylcyclohexyl formic acid, and has huge application potential.

Design, synthesis and in vitro kinetic study of tranexamic acid prodrugs for the treatment of bleeding conditions

Karaman, Rafik,Ghareeb, Hiba,Dajani, Khuloud Kamal,Scrano, Laura,Hallak, Hussein,Abu-Lafi, Saleh,Mecca, Gennaro,Bufo, Sabino A.

, p. 615 - 635 (2013/09/02)

Based on density functional theory (DFT) calculations for the acid-catalyzed hydrolysis of several maleamic acid amide derivatives four tranexamic acid prodrugs were designed. The DFT results on the acid catalyzed hydrolysis revealed that the reaction rate-limiting step is determined on the nature of the amine leaving group. When the amine leaving group was a primary amine or tranexamic acid moiety, the tetrahedral intermediate collapse was the rate-limiting step, whereas in the cases by which the amine leaving group was aciclovir or cefuroxime the rate-limiting step was the tetrahedral intermediate formation. The linear correlation between the calculated DFT and experimental rates for N-methylmaleamic acids 1-7 provided a credible basis for designing tranexamic acid prodrugs that have the potential to release the parent drug in a sustained release fashion. For example, based on the calculated B3LYP/6-31G(d,p) rates the predicted t_1/2 (a time needed for 50 % of the prodrug to be converted into drug) values for tranexamic acid prodrugs ProD 1-ProD 4 at pH 2 were 556 h [50.5 h as calculated by B3LYP/311+G(d,p)] and 6.2 h as calculated by GGA: MPW1K), 253 h, 70 s and 1.7 h, respectively. Kinetic study on the interconversion of the newly synthesized tranexamic acid prodrug ProD 1 revealed that the t_1/2 for its conversion to the parent drug was largely affected by the pH of the medium. The experimental t_1/2 values in 1 N HCl, buffer pH 2 and buffer pH 5 were 54 min, 23.9 and 270 h, respectively. Graphical Abstract: [Figure not available: see fulltext.]

Amstat Upstream and downstream

1197-18-8 Upstream product

15177-68-1

trans-4-cyanocyclohexane-1-ylcarboxylic acid
1129-35-7

4-cyanobenzoic acid methyl ester
51782-10-6

methyl 4-(acetamidomethyl)cyclohexane-1-carboxylate
15111-56-5

ethyl-3-cyclohexene-1-carboxylate
953817-12-4

C₁₂H₁₇NO₅
19145-95-0

methyl trans-4-cyanocyclohexane-1-carboxylate

1197-18-8 Downstream Products

23199-14-6

4-aminomethyl-cyclohexanecarboxylic acid methyl ester
51782-10-6

methyl 4-(acetamidomethyl)cyclohexane-1-carboxylate
79697-32-8

trans-4-(acetamidomethyl)cyclohexylcarbonylhydrazine
188715-40-4

4-[(9H-fluoren-9-ylmethoxycarbonylamino)methyl]cyclohexanecarboxylic acid
177583-51-6

trans-4-allyloxycarbonylaminomethylcyclohexanecarboxylic acid
27687-14-5

trans 4-(tert-butyloxycarbonylamino)methylcyclohexanecarboxylic acid
162046-58-4

4-(N-tert-butyloxycarbonylaminomethyl)-cyclohexane-1-carboxylic acid
1130160-84-7

C₂₁H₂₅Cl₂NO₅