Erdosteine Appearance/Package/Shipping/Storage
package
storage condition
Store in cool & dry place,Keep away from strong light and heat
Erdosteine literature
Preparation method of thioglycolic anhydride
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Paragraph 0058-0061, (2020/12/10)
The invention discloses a preparation method of thioglycolic anhydride. The method comprises the following steps of: vaporization of trifluoroacetic anhydride: vaporizing trifluoroacetic anhydride ina vaporizing device for later use; synthesis of thioglycolic anhydride: preheating the interior of a suspended gas-solid reaction device to 45-65 DEG C, introducing the vaporized trifluoroacetic anhydride into the suspended-state gas-solid reaction device, intermittently adding thionyl diacetic acid from the top of the suspended-state gas-solid reaction device, reacting for 2 hours, stopping introducing the vaporized trifluoroacetic anhydride from a gas inlet, stopping heating, and leading out an obtained solid product from a discharging port; and purification of thioglycolic anhydride: washing the solid product with refrigerated anhydrous petroleum ether and anhydrous ether respectively to obtain pure thioglycolic anhydride. The thioglycolic anhydride synthesized by the method is high inpurity and high in yield; and the yield of erdosteine prepared by reacting the thioglycolic anhydride serving as a raw material with homocysteine thiolactone hydrochloride is high.
DL-S-{2-[n-3-(2-oxo-tetrahydrothienyl)acetamido]} Thioglycolic acid: A novel mucolytic agent of the class of homocysteine thiolactone derivatives
Gobetti,Pedrazzoli,Bradamante
, p. 69 - 79 (2007/10/02)
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[(2-Oxo-3-tetrahydrothienylcarbamoyl)-alkylthio] acetic acids, their salts and esters, a process for preparation thereof and the pharmaceutical compositions containing same
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, (2008/06/13)
The present invention relates to [(2-oxo-3-tetrahydrothienylcarbamoyl)-alkylthio]-acetic acids, their salts and esters of formula: STR1 in which n is 0 or 1, one of the substituents R1 and R2 is a hydrogen atom or a methyl group and the other represents a group -S-CH2 -COOR3, where R3 is a hydrogen atom or an alkali metal or a lower alkyl group or a group: STR2 It also relates to a process for preparing said acids, salts and esters, and to the drugs containing same.
Erdosteine Upstream and downstream
84611-23-4 Upstream product
84611-23-4 Downstream Products